Autosomal Dominant Inheritance: Phenotypic Outcomes for Offspring

What are the phenotypic outcomes for the children of a woman and a man who are both heterozygous for familial hypercholesterolemia (FH) trait?

Based on the data, list down the genotypes of the parents, and determine the phenotypic outcomes for their children.

Phenotypic Outcomes for the Children:

One homozygous dominant child: FF, affected

One heterozygous child: Ff, affected

One homozygous recessive child: ff, unaffected

Detail Explanation:

In this scenario, the mother is heterozygous for FH (Ff) and the father is also heterozygous for FH (Ff). The possible genotypes for their children include FF, Ff, and ff.

As a result, the couple's offspring includes one homozygous dominant child who will be affected by the FH trait, one heterozygous child who will also be affected by the FH trait but less severely, and one homozygous recessive child who will not be affected by the FH trait.

Each child has a 50% chance of inheriting the FH gene from each parent due to the autosomal dominant nature of the trait.

Therefore, the phenotypic outcomes for the children are as follows: one homozygous dominant child affected by the FH trait, one heterozygous child affected by the FH trait, and one homozygous recessive child not affected by the FH trait.